5C8U

Crystal structure of the SARS coronavirus nsp14-nsp10 complex

5C8U の概要

• エントリーDOI: 10.2210/pdb5c8u/pdb
• 関連するPDBエントリー: 5C8S 5C8T
• 分子名称: Non-structural protein 10, Guanine-N7 methyltransferase, ZINC ION, ... (4 entities in total)
• 機能のキーワード: nsp14, nsp10, exoribonuclease, methyl transferase, transferase
• 由来する生物種: Human SARS coronavirus (SARS-CoV); 詳細
• 細胞内の位置: Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X7 P0C6X7
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151436.79

構造登録者

Ma, Y.Y.,Wu, L.J.,Zhang, R.G.,Rao, Z.H. (登録日: 2015-06-26, 公開日: 2015-07-15, 最終更新日: 2024-03-20)

• 主引用文献: Ma, Y.Y.,Wu, L.J.,Shaw, N.,Gao, Y.,Wang, J.,Sun, Y.N.,Lou, Z.Y.,Yan, L.M.,Zhang, R.G.,Rao, Z.H.; Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex; Proc.Natl.Acad.Sci.USA, 112:9436-9441, 2015; PubMed: 26159422; DOI: 10.1073/pnas.1508686112

実験手法

X-RAY DIFFRACTION (3.401 Å)