5C7L

Structure of human testis-specific glyceraldehyde-3-phosphate dehydrogenase apo form

5C7L の概要

• エントリーDOI: 10.2210/pdb5c7l/pdb
• 関連するPDBエントリー: 5C7O
• 分子名称: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (2 entities in total)
• 機能のキーワード: human sperm gapdh metabolic enzyme sperm specific, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73477.52

構造登録者

Betts, L.,Machius, M.,Danshina, P.,O'Brien, D. (登録日: 2015-06-24, 公開日: 2016-03-09, 最終更新日: 2019-12-11)

主引用文献

Danshina, P.V.,Qu, W.,Temple, B.R.,Rojas, R.J.,Miley, M.J.,Machius, M.,Betts, L.,O'Brien, D.A.
Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22:410-426, 2016

PubMed Abstract: Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive development.

PubMed: 26921398
DOI: 10.1093/molehr/gaw016

実験手法

X-RAY DIFFRACTION (1.862 Å)