5C7K

Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195

5C7K の概要

• エントリーDOI: 10.2210/pdb5c7k/pdb
• 分子名称: Antibody Fab PGT128 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• 機能のキーワード: hiv-1, sosip, pgt128, 8anc195, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 183365.48

構造登録者

Kong, L.,Stanfield, R.L.,Wilson, I.A. (登録日: 2015-06-24, 公開日: 2015-10-07, 最終更新日: 2023-09-27)

• 主引用文献: Kong, L.,Torrents de la Pena, A.,Deller, M.C.,Garces, F.,Sliepen, K.,Hua, Y.,Stanfield, R.L.,Sanders, R.W.,Wilson, I.A.; Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.; Acta Crystallogr.,Sect.D, 71:2099-2108, 2015; PubMed: 26457433; DOI: 10.1107/S1399004715013917

実験手法

X-RAY DIFFRACTION (4.6019 Å)