5C7I

Mouse sperm Glyceraldehyde-3-phosphate dehydrogenase: apo enzyme

Summary for 5C7I

• Entry DOI: 10.2210/pdb5c7i/pdb
• Descriptor: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (2 entities in total)
• Functional Keywords: testis-specific metabolic, oxidoreductase
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm : Q64467
• Total number of polymer chains: 2
• Total formula weight: 72418.43

Authors

Danshina, P.,Betts, L.,O'Brien, D. (deposition date: 2015-06-24, release date: 2016-03-09, Last modification date: 2024-11-20)

Primary citation

Danshina, P.V.,Qu, W.,Temple, B.R.,Rojas, R.J.,Miley, M.J.,Machius, M.,Betts, L.,O'Brien, D.A.
Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22:410-426, 2016

PubMed Abstract: Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive development.

PubMed: 26921398
DOI: 10.1093/molehr/gaw016

Experimental method

X-RAY DIFFRACTION (2.0098 Å)