5C7I

Mouse sperm Glyceraldehyde-3-phosphate dehydrogenase: apo enzyme

5C7I の概要

• エントリーDOI: 10.2210/pdb5c7i/pdb
• 分子名称: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (2 entities in total)
• 機能のキーワード: testis-specific metabolic, oxidoreductase
• 由来する生物種: Mus musculus (Mouse)
• 細胞内の位置: Cytoplasm : Q64467
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72418.43

構造登録者

Danshina, P.,Betts, L.,O'Brien, D. (登録日: 2015-06-24, 公開日: 2016-03-09, 最終更新日: 2024-11-20)

主引用文献

Danshina, P.V.,Qu, W.,Temple, B.R.,Rojas, R.J.,Miley, M.J.,Machius, M.,Betts, L.,O'Brien, D.A.
Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22:410-426, 2016

PubMed Abstract: Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive development.

PubMed: 26921398
DOI: 10.1093/molehr/gaw016

実験手法

X-RAY DIFFRACTION (2.0098 Å)