5C67

Human Mesotrypsin in complex with amyloid precursor protein inhibitor variant APPI-M17G/I18F/F34V

5C67 の概要

• エントリーDOI: 10.2210/pdb5c67/pdb
• 分子名称: Trypsin-3, Amyloid beta A4 protein (3 entities in total)
• 機能のキーワード: appi, kunitz domain, trypsin, hyrdolase-hydrolase inhibitor complex, hyrdolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66784.71

構造登録者

Kayode, O.,Sankaran, B.,Radisky, E.S. (登録日: 2015-06-22, 公開日: 2016-05-04, 最終更新日: 2023-09-27)

• 主引用文献: Cohen, I.,Kayode, O.,Hockla, A.,Sankaran, B.,Radisky, D.C.,Radisky, E.S.,Papo, N.; Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.; Biochem.J., 473:1329-1341, 2016; PubMed: 26957636; DOI: 10.1042/BJ20151410

実験手法

X-RAY DIFFRACTION (1.83 Å)