5C4T
Identification of a Novel Allosteric Binding Site for RORgt Inhibitors
Summary for 5C4T
Entry DOI | 10.2210/pdb5c4t/pdb |
Related | 5C4O 5C4S 5C4U |
Descriptor | Nuclear receptor ROR-gamma, (1S)-4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-1-methylcyclohex-3-ene-1-carboxylic acid, SULFATE ION, ... (5 entities in total) |
Functional Keywords | allosteric, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 1 |
Total formula weight | 29502.29 |
Authors | Parthasarathy, G.,Soisson, S. (deposition date: 2015-06-18, release date: 2015-12-16, Last modification date: 2024-03-06) |
Primary citation | Scheepstra, M.,Leysen, S.,van Almen, G.C.,Miller, J.R.,Piesvaux, J.,Kutilek, V.,van Eenennaam, H.,Zhang, H.,Barr, K.,Nagpal, S.,Soisson, S.M.,Kornienko, M.,Wiley, K.,Elsen, N.,Sharma, S.,Correll, C.C.,Trotter, B.W.,van der Stelt, M.,Oubrie, A.,Ottmann, C.,Parthasarathy, G.,Brunsveld, L. Identification of an allosteric binding site for ROR gamma t inhibition. Nat Commun, 6:8833-8833, 2015 Cited by PubMed: 26640126DOI: 10.1038/ncomms9833 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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