5C4G

Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the inhibitor BQR695 in complex with GDP loaded Rab11

Summary for 5C4G

Entry DOI	10.2210/pdb5c4g/pdb
Descriptor	Ras-related protein Rab-11A, Phosphatidylinositol 4-kinase beta, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	protein-protein complex, lipid kinase, gtpase complex, transferase-signaling protein complex, transferase/signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	86387.68
Authors	Burke, J.E.,Fowler, M.L. (deposition date: 2015-06-18, release date: 2016-01-20, Last modification date: 2023-09-27)
Primary citation	Fowler, M.L.,McPhail, J.A.,Jenkins, M.L.,Masson, G.R.,Rutaganira, F.U.,Shokat, K.M.,Williams, R.L.,Burke, J.E. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11. Protein Sci., 25:826-839, 2016 Cited by PubMed: 26756197 DOI: 10.1002/pro.2879 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation