5C37
Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a spiro-imidazolone inhibitor
5C37 の概要
エントリーDOI | 10.2210/pdb5c37/pdb |
分子名称 | Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-{[(3R)-1-(cyclopropylcarbonyl)pyrrolidin-3-yl]methyl}-5-[4-(1-methyl-1H-indazol-5-yl)phenyl]-4,6-diazaspiro[2.4]hept-4-en-7-one, ... (6 entities in total) |
機能のキーワード | fatty acid synthase, inhibitor, beta-ketoacyl reductase, cancer, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cytoplasm : P49327 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 146722.89 |
構造登録者 | Schubert, C.,Milligan, C.M.,Vo, K.,Grasberger, B. (登録日: 2015-06-17, 公開日: 2016-06-22, 最終更新日: 2023-09-27) |
主引用文献 | Lu, T.,Schubert, C.,Cummings, M.D.,Bignan, G.,Connolly, P.,Smans, K.,Ludovici, D.,Parker, M.,Meyer, C.,Rocaboy, C.,Alexander, R.,Grasberger, B.,De Breucker, S.,Esser, N.,Fraiponts, E.,Gilissen, R.,Janssens, B.,Peeters, D.,Van Nuffel, L.,Vermeulen, P.,Bischoff, J.,Meerpoel, L. Design and Synthesis of a Series of Bioavailable Fatty Acid Synthase (FASN) KR Domain Inhibitors for Cancer Therapy to be published, |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
構造検証レポート
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