5C1W

PDE10 complexed with 4,6-dichloro-2-cyclopropyl-5-methyl-pyrimidine

5C1W の概要

• エントリーDOI: 10.2210/pdb5c1w/pdb
• 関連するPDBエントリー: 5C28 5C29 5C2A 5C2E 5C2H
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q9Y233
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83373.51

構造登録者

Yan, Y. (登録日: 2015-06-15, 公開日: 2015-09-30, 最終更新日: 2024-03-06)

• 主引用文献: Shipe, W.D.,Sharik, S.S.,Barrow, J.C.,McGaughey, G.B.,Theberge, C.R.,Uslaner, J.M.,Yan, Y.,Renger, J.J.,Smith, S.M.,Coleman, P.J.,Cox, C.D.; Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.; J.Med.Chem., 58:7888-7894, 2015; PubMed: 26378882; DOI: 10.1021/acs.jmedchem.5b00983

実験手法

X-RAY DIFFRACTION (1.7 Å)