5BYJ

Schistosoma mansoni (Blood Fluke) Sulfotransferase/R-oxamniquine Complex

5BYJ の概要

• エントリーDOI: 10.2210/pdb5byj/pdb
• 関連するPDBエントリー: 5BYK
• 分子名称: Sulfotransferase, ADENOSINE-3'-5'-DIPHOSPHATE, {(2R)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol, ... (4 entities in total)
• 機能のキーワード: sulfotransferase, parasite, oxamniquine, drug resistance, transferase
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30683.10

構造登録者

Taylor, A.B.,Cao, X.,Holloway, S.P.,Hart, P.J. (登録日: 2015-06-10, 公開日: 2015-09-30, 最終更新日: 2023-09-27)

主引用文献

Taylor, A.B.,Pica-Mattoccia, L.,Polcaro, C.M.,Donati, E.,Cao, X.,Basso, A.,Guidi, A.,Rugel, A.R.,Holloway, S.P.,Anderson, T.J.,Hart, P.J.,Cioli, D.,LoVerde, P.T.
Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine.
Plos Negl Trop Dis, 9:e0004132-e0004132, 2015

PubMed Abstract: For over two decades, a racemic mixture of oxamniquine (OXA) was administered to patients infected by Schistosoma mansoni, but whether one or both enantiomers exert antischistosomal activity was unknown. Recently, a ~30 kDa S. mansoni sulfotransferase (SmSULT) was identified as the target of OXA action.

PubMed: 26485649
DOI: 10.1371/journal.pntd.0004132

実験手法

X-RAY DIFFRACTION (1.8 Å)