5BXN

Yeast 20S proteasome beta2-G170A mutant in complex with Bortezomib

Summary for 5BXN

• Entry DOI: 10.2210/pdb5bxn/pdb
• Related: 1RYP
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, immunodeficiency, proteasome, mutant, assembly defect, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); More
• Total number of polymer chains: 28
• Total formula weight: 733744.80

Authors

Huber, E.M.,Groll, M. (deposition date: 2015-06-09, release date: 2016-06-15, Last modification date: 2024-01-10)

• Primary citation: Treise, I.,Huber, E.M.,Klein-Rodewald, T.,Heinemeyer, W.,Grassmann, S.A.,Basler, M.,Adler, T.,Rathkolb, B.,Helming, L.,Andres, C.,Klaften, M.,Landbrecht, C.,Wieland, T.,Strom, T.M.,McCoy, K.D.,Macpherson, A.J.,Wolf, E.,Groettrup, M.,Ollert, M.,Neff, F.,Gailus-Durner, V.,Fuchs, H.,Hrabe de Angelis, M.,Groll, M.,Busch, D.H.; Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.; Sci Rep, 8:5975-5975, 2018; PubMed: 29654304; DOI: 10.1038/s41598-018-24199-0

Experimental method

X-RAY DIFFRACTION (2.8 Å)