5BUA

Lysine 120-acetylated P53 DNA binding domain in a complex with DNA.

5BUA の概要

• エントリーDOI: 10.2210/pdb5bua/pdb
• 分子名称: Cellular tumor antigen p53, DNA (5'-D(P*GP*GP*AP*CP*AP*TP*GP*TP*CP*C)-3'), ZINC ION, ... (4 entities in total)
• 機能のキーワード: acetylation, transcription factor, post-translational modification, tumor suppressor, dna binding specificity, apoptosis, induced fit, genetic code expansion, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25657.03

構造登録者

Arbely, E.,Vainer, R. (登録日: 2015-06-03, 公開日: 2016-07-06, 最終更新日: 2024-01-10)

• 主引用文献: Vainer, R.,Cohen, S.,Shahar, A.,Zarivach, R.,Arbely, E.; Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode.; J.Mol.Biol., 428:3013-3025, 2016; PubMed: 27338200; DOI: 10.1016/j.jmb.2016.06.009

実験手法

X-RAY DIFFRACTION (1.812 Å)