5BTS

Structural and biophysical characterization of a covalent insulin dimer formed during storage of neutral formulation of human insulin

5BTS の概要

• エントリーDOI: 10.2210/pdb5bts/pdb
• 分子名称: Insulin A chain, Insulin B chain (3 entities in total)
• 機能のキーワード: insulin, hormone, hmwp
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 5817.65

構造登録者

Norrman, M.,Hjorth, C.F. (登録日: 2015-06-03, 公開日: 2016-03-09, 最終更新日: 2019-02-20)

• 主引用文献: Hjorth, C.F.,Norrman, M.,Wahlund, P.O.,Benie, A.J.,Petersen, B.O.,Jessen, C.M.,Pedersen, T.A.,Vestergaard, K.,Steensgaard, D.B.,Pedersen, J.S.,Naver, H.,Hubalek, F.,Poulsen, C.,Otzen, D.; Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin.; J.Pharm.Sci., 105:1376-1386, 2016; PubMed: 26921119; DOI: 10.1016/j.xphs.2016.01.003

実験手法

X-RAY DIFFRACTION (1.77 Å)