5BT3

Crystal structure of EP300 bromodomain in complex with SGC-CBP30 chemical probe

Summary for 5BT3

• Entry DOI: 10.2210/pdb5bt3/pdb
• Descriptor: Histone acetyltransferase p300, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, ISOPROPYL ALCOHOL, ... (4 entities in total)
• Functional Keywords: p300, transcription regulation, histone acetyltransferase, structural genomics, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q09472
• Total number of polymer chains: 1
• Total formula weight: 14395.93

Authors

Tallant, C.,Hay, D.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Newman, J.A.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-06-02, release date: 2015-07-01, Last modification date: 2024-01-10)

• Primary citation: Tallant, C.,Hay, D.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Newman, J.A.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.; Crystal structure of EP300 bromodomain in complex with a 3,5-dimethylisoxazol ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.05 Å)