5BPO
Human insulin with intra-chain chemical crosslink between modified B27 and B29
Summary for 5BPO
Entry DOI | 10.2210/pdb5bpo/pdb |
Descriptor | Insulin (3 entities in total) |
Functional Keywords | chemical crosslink, b24-b29, specificity, hormone |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 4 |
Total formula weight | 11649.25 |
Authors | Brzozowski, A.M.,Turkenburg, J.P.,Jiracek, J.,Zakova, L. (deposition date: 2015-05-28, release date: 2016-02-03, Last modification date: 2024-01-10) |
Primary citation | Vikova, J.,Collinsova, M.,Kletvikova, E.,Budesinsky, M.,Kaplan, V.,Zakova, L.,Veverka, V.,Hexnerova, R.,Avino, R.J.,Strakova, J.,Selicharova, I.,Vanek, V.,Wright, D.W.,Watson, C.J.,Turkenburg, J.P.,Brzozowski, A.M.,Jiracek, J. Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6:19431-19431, 2016 Cited by PubMed: 26792393DOI: 10.1038/srep19431 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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