5B8C
High resolution structure of the human PD-1 in complex with pembrolizumab Fv
Summary for 5B8C
Entry DOI | 10.2210/pdb5b8c/pdb |
Descriptor | Pembrolizumab light chain variable region (PemVL), Pembrolizumab heavy chain variable region (PemVH), Programmed cell death protein 1, ... (4 entities in total) |
Functional Keywords | antibody, immune system |
Biological source | Homo sapiens More |
Cellular location | Membrane; Single-pass type I membrane protein: Q15116 |
Total number of polymer chains | 12 |
Total formula weight | 168002.49 |
Authors | Horita, S.,Shimamura, T.,Iwata, S.,Nomura, N. (deposition date: 2016-06-14, release date: 2016-10-26, Last modification date: 2023-11-08) |
Primary citation | Horita, S.,Nomura, Y.,Sato, Y.,Shimamura, T.,Iwata, S.,Nomura, N. High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1 Sci Rep, 6:35297-35297, 2016 Cited by PubMed: 27734966DOI: 10.1038/srep35297 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.146 Å) |
Structure validation
Download full validation report