5B6M

Crystal structure of human peroxiredoxin 6 in reduced state

5B6M の概要

• エントリーDOI: 10.2210/pdb5b6m/pdb
• 関連するPDBエントリー: 5B6N
• 分子名称: Peroxiredoxin-6 (2 entities in total)
• 機能のキーワード: prx6, 1-cys prx, catalytic site, oxidation, reduction, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P30041
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 150407.83

構造登録者

Kim, K.H.,Lee, W.T.,Kim, E.E. (登録日: 2016-05-30, 公開日: 2016-07-13, 最終更新日: 2023-11-08)

主引用文献

Kim, K.H.,Lee, W.T.,Kim, E.E.
Crystal structures of human peroxiredoxin 6 in different oxidation states
Biochem.Biophys.Res.Commun., 477:717-722, 2016

PubMed Abstract: Peroxiredoxins (Prxs) are a family of antioxidant enzymes found ubiquitously. Prxs function not only as H2O2 scavengers but also as highly sensitive H2O2 sensors and signal transducers. Since reactive oxygen species are involved in many cellular metabolic and signaling processes, Prxs play important roles in various diseases. Prxs can be hyperoxidized to the sulfinic acid (SO2H) or sulfonic acid (SO3H) forms in the presence of high concentrations of H2O2. It is known that oligomerization of Prx is changed accompanying oxidation states, and linked to the function. Among the six Prxs in mammals, Prx6 is the only 1-Cys Prx. It is found in all organs in humans, unlike some 2-Cys Prxs, and is present in all species from bacteria to humans. In addition, Prx6 has Ca(2+)-independent phospholipase A2 (PLA2) activity. Thus far only the crystal structure of Prx in the oxidized state has been reported. In this study, we present the crystal structures of human Prx6 in the reduced (SH) and the sulfinic acid (SO2H) forms.

PubMed: 27353378
DOI: 10.1016/j.bbrc.2016.06.125

実験手法

X-RAY DIFFRACTION (2.496 Å)