5B41
Crystal structure of VDR-LBD complexed with 2-methylidene-19-nor-1a,25-dihydroxyvitamin D3
Summary for 5B41
Entry DOI | 10.2210/pdb5b41/pdb |
Descriptor | Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2- methylenecyclohexane-1,3-diol, ... (4 entities in total) |
Functional Keywords | transcription, vitamin d3, vdr, vdre, rxr, co-factors |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 32582.57 |
Authors | Anami, Y.,Itoh, T.,Yamamoto, K. (deposition date: 2016-03-23, release date: 2016-12-07, Last modification date: 2023-11-08) |
Primary citation | Anami, Y.,Shimizu, N.,Ekimoto, T.,Egawa, D.,Itoh, T.,Ikeguchi, M.,Yamamoto, K. Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-ray Scattering and Molecular Dynamics J.Med.Chem., 59:7888-7900, 2016 Cited by PubMed: 27535484DOI: 10.1021/acs.jmedchem.6b00682 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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