5B39

KIR3DL1*015 in complex with HLA-B*57:01

5B39 の概要

• エントリーDOI: 10.2210/pdb5b39/pdb
• 関連するPDBエントリー: 3VH8 5B38
• 分子名称: HLA class I histocompatibility antigen, B-57 alpha chain, Beta-2-microglobulin, peptide from Ig kappa chain C region, ... (6 entities in total)
• 機能のキーワード: innate immune receptor, kir, natural killer cell, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 78144.43

構造登録者

Vivian, J.P.,Rossjohn, J. (登録日: 2016-02-12, 公開日: 2016-03-30, 最終更新日: 2024-11-06)

主引用文献

Saunders, P.M.,Pymm, P.,Pietra, G.,Hughes, V.A.,Hitchen, C.,O'Connor, G.M.,Loiacono, F.,Widjaja, J.,Price, D.A.,Falco, M.,Mingari, M.C.,Moretta, L.,McVicar, D.W.,Rossjohn, J.,Brooks, A.G.,Vivian, J.P.
Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition
J.Exp.Med., 213:791-807, 2016

PubMed Abstract: Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were screened for reactivity against a panel of HLA-I molecules. This revealed different and distinct hierarchies of specificity for each KIR3DL1 allotype, with KIR3DL1*005 recognizing the widest array of HLA-I ligands. These differences were further reflected in functional studies using NK clones expressing these specific KIR3DL1 allotypes. Unexpectedly, the Ile/Thr80 dimorphism in the Bw4-motif did not categorically define strong/weak KIR3DL1 recognition. Although the KIR3DL1*001, *005, and *015 polymorphisms are remote from the KIR3DL1-HLA-I interface, the structures of these three KIR3DL1-HLA-I complexes showed that the broader HLA-I specificity of KIR3DL1*005 correlated with an altered KIR3DL1*005 interdomain positioning and increased mobility within its ligand-binding site. Collectively, we provide a generic framework for understanding the impact of KIR3DL1 polymorphism on the recognition of HLA-I allomorphs.

PubMed: 27045007
DOI: 10.1084/jem.20152023

実験手法

X-RAY DIFFRACTION (2.5 Å)