5B25

Crystal structure of human PDE1B with inhibitor 3

5B25 の概要

• エントリーDOI: 10.2210/pdb5b25/pdb
• 分子名称: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q01064
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 158383.14

構造登録者

Ida, K.,Lane, W.,Snell, G.,Sogabe, S. (登録日: 2016-01-07, 公開日: 2016-02-03, 最終更新日: 2023-11-08)

• 主引用文献: Li, P.,Zheng, H.,Zhao, J.,Zhang, L.,Yao, W.,Zhu, H.,Beard, J.D.,Ida, K.,Lane, W.,Snell, G.,Sogabe, S.,Heyser, C.J.,Snyder, G.L.,Hendrick, J.P.,Vanover, K.E.,Davis, R.E.,Wennogle, L.P.; Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases; J.Med.Chem., 59:1149-1164, 2016; PubMed: 26789933; DOI: 10.1021/acs.jmedchem.5b01751

実験手法

X-RAY DIFFRACTION (1.9 Å)