5AR3

RIP2 Kinase Catalytic Domain (1 - 310) complex with AMP-PCP

Summary for 5AR3

Entry DOI	10.2210/pdb5ar3/pdb
Related	5AR2 5AR4 5AR5 5AR7 5AR8
Descriptor	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	transferase, kinase inhibitor, structure-based drug design, inhibitor selectivity
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : O43353
Total number of polymer chains	2
Total formula weight	76270.99
Authors	Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L. (deposition date: 2015-09-23, release date: 2015-10-21, Last modification date: 2018-04-04)
Primary citation	Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Ouellette, M.,Totoritis, R.,Schwartz, B.,King, B.W.,Wisnoski, D.D.,Kang, J.,Eidam, P.M.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L. Crystal Structures of Human Rip2 Kinase Catalytic Domain Complexed with ATP-Competitive Inhibitors: Foundations for Understanding Inhibitor Selectivity. Bioorg.Med.Chem., 23:7000-, 2015 Cited by PubMed: 26455654 DOI: 10.1016/J.BMC.2015.09.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.23 Å)

Structure validation