5AQG
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
5AQG の概要
エントリーDOI | 10.2210/pdb5aqg/pdb |
関連するPDBエントリー | 5AQF 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 5AQW 5AQX 5AQY 5AQZ 5AR0 |
分子名称 | HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, (2R,3R,4S,5R)-2-(3-AMINO-5-METHYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-1(5H)-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (7 entities in total) |
機能のキーワード | heat shock protein, hsp70, hsp72, hsc70, atpase, bag1, chaperone, fragment |
由来する生物種 | HOMO SAPIENS (HUMAN) 詳細 |
細胞内の位置 | Cytoplasm: P11142 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 4: Cytoplasm: Q99933 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 170136.88 |
構造登録者 | Jones, A.M.,Westwood, I.M.,Osborne, J.D.,Matthews, T.P.,Cheeseman, M.D.,Rowlands, M.G.,Jeganathan, F.,Burke, R.,Lee, D.,Kadi, N.,Liu, M.,Richards, M.,McAndrew, C.,Yahya, N.,Dobson, S.E.,Jones, K.,Workman, P.,Collins, I.,van Montfort, R.L.M. (登録日: 2015-09-22, 公開日: 2016-10-05, 最終更新日: 2024-01-10) |
主引用文献 | Jones, A.M.,Westwood, I.M.,Osborne, J.D.,Matthews, T.P.,Cheeseman, M.D.,Rowlands, M.G.,Jeganathan, F.,Burke, R.,Lee, D.,Kadi, N.,Liu, M.,Richards, M.,McAndrew, C.,Yahya, N.,Dobson, S.E.,Jones, K.,Workman, P.,Collins, I.,van Montfort, R.L. A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6:34701-34701, 2016 Cited by PubMed: 27708405DOI: 10.1038/srep34701 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.24 Å) |
構造検証レポート
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