5APK
Ligand complex of RORg LBD
Summary for 5APK
Entry DOI | 10.2210/pdb5apk/pdb |
Related | 5APH 5APJ |
Descriptor | NUCLEAR RECEPTOR ROR-GAMMA, 2-CHLORO-6-FLUORO-N-[4-[3-(TRIFLUOROMETHYL)PHENYL]SULFONYL-3,5-DIHYDRO-2H-1,4-BENZOXAZEPIN-7-YL]BENZAMIDE, ... (4 entities in total) |
Functional Keywords | transcription, rorg ligand, rorg agonist, structure-based design |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus : P51449 P51449 |
Total number of polymer chains | 3 |
Total formula weight | 64527.71 |
Authors | Xue, Y.,Aagaard, A.,Narjes, F. (deposition date: 2015-09-16, release date: 2015-11-25, Last modification date: 2024-01-10) |
Primary citation | Olsson, R.I.,Xue, Y.,von Berg, S.,Aagaard, A.,McPheat, J.,Hansson, E.L.,Bernstrom, J.,Hansson, P.,Jirholt, J.,Grindebacke, H.,Leffler, A.,Chen, R.,Xiong, Y.,Ge, H.,Hansson, T.G.,Narjes, F. Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor ROR gamma. ChemMedChem, 11:207-216, 2016 Cited by PubMed: 26553345DOI: 10.1002/cmdc.201500432 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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