Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5AP6

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Summary for 5AP6
Entry DOI10.2210/pdb5ap6/pdb
Related5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP7
DescriptorDUAL SPECIFICITY PROTEIN KINASE TTK, ISOPROPYL 6-((4-(1,2-DIMETHYL-1H-IMIDAZOL-5-YL)PHENYL)AMINO)-2-(1-METHYL-1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLATE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordstransferase, mps1, mitosis
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight37366.67
Authors
Primary citationGurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.J.,Mcandrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,Van Montfort, R.L.M.,Linardopoulos, S.
Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Cancer Res., 75:3340-, 2015
Cited by
PubMed: 26202014
DOI: 10.1158/0008-5472.CAN-14-3272
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon