5AON

Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei

5AON の概要

• エントリーDOI: 10.2210/pdb5aon/pdb
• 分子名称: PEROXIN 14, SULFATE ION (3 entities in total)
• 機能のキーワード: peroxisomal matrix protein import receptor, signaling protein
• 由来する生物種: TRYPANOSOMA BRUCEI
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 30032.13

構造登録者

Obita, T.,Sugawara, Y.,Mizuguchi, M.,Watanabe, Y.,Kawaguchi, K.,Imanaka, T. (登録日: 2015-09-11, 公開日: 2015-12-23, 最終更新日: 2024-01-10)

主引用文献

Watanabe, Y.,Kawaguchi, K.,Okuyama, N.,Sugawara, Y.,Obita, T.,Mizuguchi, M.,Morita, M.,Imanaka, T.
Characterization of the Interaction between Trypanosoma Brucei Pex5P and its Receptor Pex14P.
FEBS Lett., 590:242-, 2016

PubMed Abstract: The interaction of Trypanosoma brucei (Tb) Pex5p and its receptor TbPex14p is essential for the translocation of newly synthesized matrix proteins into the glycosome. Here, we reveal that only the third WXXXF/Y motif of TbPex5p is involved in the interaction and that negative charge of the fourth amino acid is important. We suggest that Phe35 and Phe52 of TbPex14p interact with Trp318 and Phe322 in the third motif and that the Lys56 adjacent to Phe35/Phe52 associates with the fourth Glu in the motif to make the complex. This information is expected to be useful for developing anti-trypanosomal drugs.

PubMed: 26762183
DOI: 10.1002/1873-3468.12044

実験手法

X-RAY DIFFRACTION (1.646 Å)