5AOH

Crystal Structure of CarF

5AOH の概要

• エントリーDOI: 10.2210/pdb5aoh/pdb
• 分子名称: Spore coat protein CotH, POTASSIUM ION (3 entities in total)
• 機能のキーワード: unknown function, carbapenem resistance, antibiotic resistance, fge homologue
• 由来する生物種: Serratia sp. (strain ATCC 39006)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59966.29

構造登録者

Tichy, E.M.,Hardwick, S.W.,Luisi, B.F.,C Salmond, G.P. (登録日: 2015-09-10, 公開日: 2017-01-25, 最終更新日: 2024-10-23)

主引用文献

Tichy, E.M.,Hardwick, S.W.,Luisi, B.F.,Salmond, G.P.C.
1.8 angstrom resolution crystal structure of the carbapenem intrinsic resistance protein CarF.
Acta Crystallogr D Struct Biol, 73:549-556, 2017

PubMed Abstract: The natural production of the β-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived.

PubMed: 28695855
DOI: 10.1107/S2059798317002236

実験手法

X-RAY DIFFRACTION (1.8 Å)