5ANQ

inhibitors of JumonjiC domain-containing histone demethylases

Summary for 5ANQ

• Entry DOI: 10.2210/pdb5anq/pdb
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 4A, 2-{2-[(pyridin-3-ylmethyl)amino]pyrimidin-4-yl}pyridine-4-carboxylic acid, FE (II) ION, ... (7 entities in total)
• Functional Keywords: oxidoreductase, epigenetics, histone demethylases, inhibitors, jumonjic domain, virtual screening
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : O75164
• Total number of polymer chains: 2
• Total formula weight: 84918.27

Authors

Roatsch, M.,Robaa, D.,Pippel, M.,Nettleship, J.E.,Reddivari, Y.,Bird, L.E.,Hoffmann, I.,Franz, H.,Owens, R.J.,Schuele, R.,Flaig, R.,Sippl, W.,Jung, M. (deposition date: 2015-09-07, release date: 2016-03-23, Last modification date: 2024-01-10)

• Primary citation: Roatsch, M.,Robaa, D.,Pippel, M.,Nettleship, J.E.,Reddivari, Y.,Bird, L.E.,Hoffmann, I.,Franz, H.,Owens, R.J.,Schole, R.,Flaig, R.,Sippl, W.,Jung, M.; Substituted 2-(2-Aminopyrimidin-4-Yl)Pyridine-4-Carboxylates as Potent Inhibitors of Jumonjic Domain-Containing Histone Demethylases.; Fut.Med.Chem., 8:1553-, 2016; PubMed: 26971619; DOI: 10.4155/FMC.15.188

Experimental method

X-RAY DIFFRACTION (2 Å)