5ANL

Crystal structure of VPS34 in complex with (2S)-8-((3R)-3- Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3, 4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one, processed with the CrystalDirect automated mounting and cryo-cooling technology

Summary for 5ANL

Entry DOI	10.2210/pdb5anl/pdb
Related	5AMW 5AMX 5AMY 5AMZ 5AN2 5AN4 5AND 5ANE 5ANG 5ANI 5ANJ 5ANK 5ANO
Descriptor	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, (8S)-2-(morpholin-4-yl)-9-[2-(propan-2-yloxy)ethyl]-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one (3 entities in total)
Functional Keywords	transferase, lipid kinase, automated crystal harvesting, automated cryo- cooling, crystaldirect
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Midbody : Q8NEB9
Total number of polymer chains	1
Total formula weight	68987.79
Authors	Zander, U.,Hoffmann, G.,Mathieu, M.,Marquette, J.-P.,Cornaciu, I.,Cipriani, F.,Marquez, J.A. (deposition date: 2015-09-07, release date: 2016-04-13, Last modification date: 2024-05-08)
Primary citation	Zander, U.,Hoffmann, G.,Cornaciu, I.,Marquette, J.-P.,Papp, G.,Landret, C.,Seroul, G.,Sinoir, J.,Roewer, M.,Felisaz, F.,Rodriguez-Puente, S.,Mariaule, V.,Murphy, P.,Mathieu, M.,Cipriani, F.,Marquez, J.A. Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation. Acta Crystallogr.,Sect.D, 72:454-, 2016 Cited by PubMed: 27050125 DOI: 10.1107/S2059798316000954 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation