5ANL

Crystal structure of VPS34 in complex with (2S)-8-((3R)-3- Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3, 4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one, processed with the CrystalDirect automated mounting and cryo-cooling technology

5ANL の概要

• エントリーDOI: 10.2210/pdb5anl/pdb
• 関連するPDBエントリー: 5AMW 5AMX 5AMY 5AMZ 5AN2 5AN4 5AND 5ANE 5ANG 5ANI 5ANJ 5ANK 5ANO
• 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, (8S)-2-(morpholin-4-yl)-9-[2-(propan-2-yloxy)ethyl]-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one (3 entities in total)
• 機能のキーワード: transferase, lipid kinase, automated crystal harvesting, automated cryo- cooling, crystaldirect
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Midbody : Q8NEB9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 68987.79

構造登録者

Zander, U.,Hoffmann, G.,Mathieu, M.,Marquette, J.-P.,Cornaciu, I.,Cipriani, F.,Marquez, J.A. (登録日: 2015-09-07, 公開日: 2016-04-13, 最終更新日: 2024-05-08)

• 主引用文献: Zander, U.,Hoffmann, G.,Cornaciu, I.,Marquette, J.-P.,Papp, G.,Landret, C.,Seroul, G.,Sinoir, J.,Roewer, M.,Felisaz, F.,Rodriguez-Puente, S.,Mariaule, V.,Murphy, P.,Mathieu, M.,Cipriani, F.,Marquez, J.A.; Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation.; Acta Crystallogr.,Sect.D, 72:454-, 2016; PubMed: 27050125; DOI: 10.1107/S2059798316000954

実験手法

X-RAY DIFFRACTION (2.7 Å)