5AN7
Structure of the engineered retro-aldolase RA95.5-8F with a bound 1,3-diketone inhibitor
Summary for 5AN7
Entry DOI | 10.2210/pdb5an7/pdb |
Related | 5AOU |
Descriptor | RA95.5-8F, PHOSPHATE ION, (2E)-1-(6-methoxynaphthalen-2-yl)but-2-en-1-one, ... (4 entities in total) |
Functional Keywords | lyase, retro-aldolase, protein engineering, enzyme design, directed evolution |
Biological source | SULFOLOBUS SOLFATARICUS |
Total number of polymer chains | 1 |
Total formula weight | 30352.65 |
Authors | Obexer, R.,Mittl, P.R.E.,Hilvert, D. (deposition date: 2015-09-04, release date: 2016-08-17, Last modification date: 2024-01-10) |
Primary citation | Obexer, R.,Godina, A.,Garrabou, X.,Mittl, P.R.,Baker, D.,Griffiths, A.D.,Hilvert, D. Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase. Nat Chem, 9:50-56, 2017 Cited by PubMed: 27995916DOI: 10.1038/nchem.2596 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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