5AMF

Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment Ethyl 4,5,6,7- tetrahydro-1H-indazole-5-carboxylate (SGC - Diamond I04-1 fragment screening)

Summary for 5AMF

• Entry DOI: 10.2210/pdb5amf/pdb
• Related: 5AME
• Descriptor: BROMODOMAIN-CONTAINING PROTEIN 1, ETHYL (5R)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE-5-CARBOXYLATE, SODIUM ION, ... (4 entities in total)
• Functional Keywords: histone-binding protein, bromodomain, epigenetic, fragmentscreening, structural genomics consortium, sgc, diamond i04-1
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 31723.24

Authors

Pearce, N.M.,Fairhead, M.,Strain-Damerell, C.,Talon, R.,Wright, N.,Ng, J.T.,Bradley, A.,Cox, O.,Bowkett, D.,Collins, P.,Brandao-Neto, J.,Douangamath, A.,Krojer, T.,Burgess-Brown, N.,Brennan, P.,Arrowsmith, C.H.,Edwards, E.,Bountra, C.,von Delft, F. (deposition date: 2015-03-10, release date: 2015-03-18, Last modification date: 2019-03-06)

• Primary citation: Pearce, N.M.,Fairhead, M.,Strain-Damerell, C.,Talon, R.,Wright, N.,Ng, J.T.,Bradley, A.,Cox, O.,Bowkett, D.,Collins, P.,Brandao-Neto, J.,Douangamath, A.,Krojer, T.,Burgess-Brown, N.,Brennan, P.,Arrowsmith, C.H.,Edwards, E.,Bountra, C.,von Delft, F.; Crystal Structure of the Bromodomain of Human Surface Epitope Engineered Brd1A in Complex with 3D Consortium Fragment Ethyl 4,5,6,7-Tetrahydro-1H-Indazole-5-Carboxylate; To be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)