5AMF

Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment Ethyl 4,5,6,7- tetrahydro-1H-indazole-5-carboxylate (SGC - Diamond I04-1 fragment screening)

5AMF の概要

• エントリーDOI: 10.2210/pdb5amf/pdb
• 関連するPDBエントリー: 5AME
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 1, ETHYL (5R)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE-5-CARBOXYLATE, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: histone-binding protein, bromodomain, epigenetic, fragmentscreening, structural genomics consortium, sgc, diamond i04-1
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31723.24

構造登録者

Pearce, N.M.,Fairhead, M.,Strain-Damerell, C.,Talon, R.,Wright, N.,Ng, J.T.,Bradley, A.,Cox, O.,Bowkett, D.,Collins, P.,Brandao-Neto, J.,Douangamath, A.,Krojer, T.,Burgess-Brown, N.,Brennan, P.,Arrowsmith, C.H.,Edwards, E.,Bountra, C.,von Delft, F. (登録日: 2015-03-10, 公開日: 2015-03-18, 最終更新日: 2024-05-01)

• 主引用文献: Pearce, N.M.,Fairhead, M.,Strain-Damerell, C.,Talon, R.,Wright, N.,Ng, J.T.,Bradley, A.,Cox, O.,Bowkett, D.,Collins, P.,Brandao-Neto, J.,Douangamath, A.,Krojer, T.,Burgess-Brown, N.,Brennan, P.,Arrowsmith, C.H.,Edwards, E.,Bountra, C.,von Delft, F.; Crystal Structure of the Bromodomain of Human Surface Epitope Engineered Brd1A in Complex with 3D Consortium Fragment Ethyl 4,5,6,7-Tetrahydro-1H-Indazole-5-Carboxylate; To be Published,

実験手法

X-RAY DIFFRACTION (1.75 Å)