5AME

Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)

5AME の概要

• エントリーDOI: 10.2210/pdb5ame/pdb
• 関連するPDBエントリー: 5AMF
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 1, 4-acetyl-piperazin-2-one, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: transcription, histone-binding protein, bromodomain, epigenetic, fragmentscreening, structural genomics consortium, sgc, diamond i04-1
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31671.16

構造登録者

Pearce, N.M.,Fairhead, M.,Strain-Damerell, C.,Talon, R.,Wright, N.,Ng, J.T.,Bradley, A.,Cox, O.,Bowkett, D.,Collins, P.,Brandao-Neto, J.,Douangamath, A.,Krojer, T.,Burgess-Brown, N.,Brennan, P.,Arrowsmith, C.H.,Edwards, E.,Bountra, C.,von Delft, F. (登録日: 2015-03-10, 公開日: 2015-03-18, 最終更新日: 2019-03-06)

• 主引用文献: Pearce, N.M.,Fairhead, M.,Strain-Damerell, C.,Talon, R.,Wright, N.,Ng, J.T.,Bradley, A.,Cox, O.,Bowkett, D.,Collins, P.,Brandao-Neto, J.,Douangamath, A.,Krojer, T.,Burgess-Brown, N.,Brennan, P.,Arrowsmith, C.H.,Edwards, E.,Bountra, C.,von Delft, F.; Crystal Structure of the Bromodomain of Human Surface Epitope Engineered Brd1A in Complex with 3D Consortium Fragment 4-Acetyl-Piperazin-2-One; To be Published,

実験手法

X-RAY DIFFRACTION (1.578 Å)