5AK8

Structure of C351A mutant of Porphyromonas gingivalis peptidylarginine deiminase

5AK8 の概要

• エントリーDOI: 10.2210/pdb5ak8/pdb
• 関連するPDBエントリー: 5AK7
• 分子名称: PEPTIDYLARGININE DEIMINASE, ALANINE, ARGININE, ... (6 entities in total)
• 機能のキーワード: hydrolase, ppad
• 由来する生物種: PORPHYROMONAS GINGIVALIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50311.16

構造登録者

Kopec, J.,Montgomery, A.,Shrestha, L.,Kiyani, W.,Nowak, R.,Burgess-Brown, N.,Venables, P.J.,Yue, W.W. (登録日: 2015-03-02, 公開日: 2015-07-22, 最終更新日: 2024-05-08)

主引用文献

Montgomery, A.B.,Kopec, J.,Shrestha, L.,Thezenas, M.L.,Burgess-Brown, N.A.,Fischer, R.,Yue, W.W.,Venables, P.J.
Crystal Structure of Porphyromonas Gingivalis Peptidylarginine Deiminase: Implications for Autoimmunity in Rheumatoid Arthritis.
Ann.Rheum.Dis., 75:1255-, 2016

PubMed Abstract: Periodontitis (PD) is a known risk factor for rheumatoid arthritis (RA) and there is increasing evidence that the link between the two diseases is due to citrullination by the unique bacterial peptidylarginine deiminase (PAD) enzyme expressed by periodontal pathogen Pophyromonas gingivalis (PPAD). However, the precise mechanism by which PPAD could generate potentially immunogenic peptides has remained controversial due to lack of information about the structural and catalytic mechanisms of the enzyme.

PubMed: 26209657
DOI: 10.1136/ANNRHEUMDIS-2015-207656

実験手法

X-RAY DIFFRACTION (1.48 Å)