5AJW

Human PFKFB3 in complex with an indole inhibitor 2

Summary for 5AJW

• Entry DOI: 10.2210/pdb5ajw/pdb
• Related: 5AJV 5AJX 5AJY 5AJZ 5AK0
• Descriptor: 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, PHOSPHONIC ACID, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 60542.70

Authors

Boyd, S.,Brookfield, J.L.,Critchlow, S.E.,Cumming, I.A.,Curtis, N.J.,Debreczeni, J.E.,Degorce, S.L.,Donald, C.,Evans, N.J.,Groombridge, S.,Hopcroft, P.,Jones, N.P.,Kettle, J.G.,Lamont, S.,Lewis, H.J.,MacFaull, P.,McLoughlin, S.B.,Rigoreau, L.J.M.,Smith, J.M.,St-Gallay, S.,Stock, J.K.,Wheatley, E.R.,Winter, J.,Wingfield, J. (deposition date: 2015-02-27, release date: 2015-04-22, Last modification date: 2024-05-08)

• Primary citation: Boyd, S.,Brookfield, J.L.,Critchlow, S.E.,Cumming, I.A.,Curtis, N.J.,Debreczeni, J.,Degorce, S.L.,Donald, C.,Evans, N.J.,Groombridge, S.,Hopcroft, P.,Jones, N.P.,Kettle, J.G.,Lamont, S.,Lewis, H.J.,Macfaull, P.,Mcloughlin, S.B.,Rigoreau, L.J.M.,Smith, J.M.,St-Gallay, S.,Stock, J.K.,Turnbull, A.P.,Wheatley, E.R.,Winter, J.,Wingfield, J.; Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.; J.Med.Chem., 58:3611-, 2015; PubMed: 25849762; DOI: 10.1021/ACS.JMEDCHEM.5B00352

Experimental method