5AJV

Human PFKFB3 in complex with an indole inhibitor 1

Summary for 5AJV

Entry DOI	10.2210/pdb5ajv/pdb
Related	5AJW 5AJX 5AJY 5AJZ 5AK0
Descriptor	HUMAN PFKFB3, PHOSPHATE ION, (2S)-2-amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxy-propanamide, ... (5 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	60670.53
Authors	Boyd, S.,Brookfield, J.L.,Critchlow, S.E.,Cumming, I.A.,Curtis, N.J.,Debreczeni, J.E.,Degorce, S.L.,Donald, C.,Evans, N.J.,Groombridge, S.,Hopcroft, P.,Jones, N.P.,Kettle, J.G.,Lamont, S.,Lewis, H.J.,MacFaull, P.,McLoughlin, S.B.,Rigoreau, L.J.M.,Smith, J.M.,St-Gallay, S.,Stock, J.K.,Wheatley, E.R.,Winter, J.,Wingfield, J. (deposition date: 2015-02-27, release date: 2015-04-22, Last modification date: 2024-05-08)
Primary citation	Boyd, S.,Brookfield, J.L.,Critchlow, S.E.,Cumming, I.A.,Curtis, N.J.,Debreczeni, J.,Degorce, S.L.,Donald, C.,Evans, N.J.,Groombridge, S.,Hopcroft, P.,Jones, N.P.,Kettle, J.G.,Lamont, S.,Lewis, H.J.,Macfaull, P.,Mcloughlin, S.B.,Rigoreau, L.J.M.,Smith, J.M.,St-Gallay, S.,Stock, J.K.,Turnbull, A.P.,Wheatley, E.R.,Winter, J.,Wingfield, J. Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3. J.Med.Chem., 58:3611-, 2015 Cited by PubMed: 25849762 DOI: 10.1021/ACS.JMEDCHEM.5B00352 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.01 Å)

Structure validation