5AJV

Human PFKFB3 in complex with an indole inhibitor 1

5AJV の概要

• エントリーDOI: 10.2210/pdb5ajv/pdb
• 関連するPDBエントリー: 5AJW 5AJX 5AJY 5AJZ 5AK0
• 分子名称: HUMAN PFKFB3, PHOSPHATE ION, (2S)-2-amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxy-propanamide, ... (5 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60670.53

構造登録者

Boyd, S.,Brookfield, J.L.,Critchlow, S.E.,Cumming, I.A.,Curtis, N.J.,Debreczeni, J.E.,Degorce, S.L.,Donald, C.,Evans, N.J.,Groombridge, S.,Hopcroft, P.,Jones, N.P.,Kettle, J.G.,Lamont, S.,Lewis, H.J.,MacFaull, P.,McLoughlin, S.B.,Rigoreau, L.J.M.,Smith, J.M.,St-Gallay, S.,Stock, J.K.,Wheatley, E.R.,Winter, J.,Wingfield, J. (登録日: 2015-02-27, 公開日: 2015-04-22, 最終更新日: 2024-05-08)

• 主引用文献: Boyd, S.,Brookfield, J.L.,Critchlow, S.E.,Cumming, I.A.,Curtis, N.J.,Debreczeni, J.,Degorce, S.L.,Donald, C.,Evans, N.J.,Groombridge, S.,Hopcroft, P.,Jones, N.P.,Kettle, J.G.,Lamont, S.,Lewis, H.J.,Macfaull, P.,Mcloughlin, S.B.,Rigoreau, L.J.M.,Smith, J.M.,St-Gallay, S.,Stock, J.K.,Turnbull, A.P.,Wheatley, E.R.,Winter, J.,Wingfield, J.; Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.; J.Med.Chem., 58:3611-, 2015; PubMed: 25849762; DOI: 10.1021/ACS.JMEDCHEM.5B00352

実験手法

X-RAY DIFFRACTION (3.01 Å)