5AJ1

Solution Structure of the Smarc Domain

5AJ1 の概要

• エントリーDOI: 10.2210/pdb5aj1/pdb
• NMR情報: BMRB: 26553
• 分子名称: SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1 (1 entity in total)
• 機能のキーワード: structural protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: Q12824
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12995.91

構造登録者

Allen, M.D.,Freund, S.M.V.,Zinzalla, G.,Bycroft, M. (登録日: 2015-02-19, 公開日: 2015-08-05, 最終更新日: 2024-06-19)

主引用文献

Allen, M.D.,Freund, S.M.V.,Zinzalla, G.,Bycroft, M.
The Swi/Snf Subunit Ini1 Contains an N-Terminal Winged Helix DNA Binding Domain that is a Target for Mutations in Schwannomatosis.
Structure, 23:1344-, 2015

PubMed Abstract: SWI/SNF complexes use the energy of ATP hydrolysis to remodel chromatin. In mammals they play a central role in regulating gene expression during differentiation and proliferation. Mutations in SWI/SNF subunits are among the most frequent gene alterations in cancer. The INI1/hSNF5/SMARCB1 subunit is mutated in both malignant rhabdoid tumor, a highly aggressive childhood cancer, and schwannomatosis, a tumor-predisposing syndrome characterized by mostly benign tumors of the CNS. Here, we show that mutations in INI1 that cause schwannomatosis target a hitherto unidentified N-terminal winged helix DNA binding domain that is also present in the BAF45a/PHF10 subunit of the SWI/SNF complex. The domain is structurally related to the SKI/SNO/DAC domain, which is found in a number of metazoan chromatin-associated proteins.

PubMed: 26073604
DOI: 10.1016/J.STR.2015.04.021

実験手法

SOLUTION NMR