5AI4

ligand complex structure of soluble epoxide hydrolase

Summary for 5AI4

• Entry DOI: 10.2210/pdb5ai4/pdb
• Related: 5AHX 5AI0 5AI5 5AI6 5AI8 5AI9 5AIA 5AIB 5AIC
• Descriptor: BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P34913
• Total number of polymer chains: 1
• Total formula weight: 63025.78

Authors

Oster, L.,Tapani, S.,Xue, Y.,Kack, H. (deposition date: 2015-02-12, release date: 2015-05-13, Last modification date: 2024-01-10)

Primary citation

Oster, L.,Tapani, S.,Xue, Y.,Kack, H.
Successful Generation of Structural Information for Fragment-Based Drug Discovery.
Drug Discov Today, 20:1104-, 2015

PubMed Abstract: Fragment-based drug discovery relies upon structural information for efficient compound progression, yet it is often challenging to generate structures with bound fragments. A summary of recent literature reveals that a wide repertoire of experimental procedures is employed to generate ligand-bound crystal structures successfully. We share in-house experience from setting up and executing fragment crystallography in a project that resulted in 55 complex structures. The ligands span five orders of magnitude in affinity and the resulting structures are made available to be of use, for example, for development of computational methods. Analysis of the results revealed that ligand properties such as potency, ligand efficiency (LE) and, to some degree, clogP influence the success of complex structure generation.

PubMed: 25931264
DOI: 10.1016/J.DRUDIS.2015.04.005

Experimental method

X-RAY DIFFRACTION (1.93 Å)