5AHC
Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
Summary for 5AHC
Entry DOI | 10.2210/pdb5ahc/pdb |
Related | 5AGZ 5AH6 5AH7 5AH8 5AH9 5AHA 5AHB |
Descriptor | PROTEASE, CHLORIDE ION, (3R,3aS,4R,6aR)-4-[2-(methylamino)-2-oxoethoxy]hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, ... (4 entities in total) |
Functional Keywords | hydrolase, inhibitor, rational drug design bis-thf bis-diol |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (Z2/CDC-Z34 ISOLATE) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22307.43 |
Authors | Hohlfeld, K.,Wegner, J.K.,Kesteleyn, B.,Linclau, B.,Unge, J. (deposition date: 2015-02-05, release date: 2015-05-06, Last modification date: 2024-05-01) |
Primary citation | Hohlfeld, K.,Wegner, J.,Kesteleyn, B.,Linclau, B.,Unge, J. Disubstituted Bis-Thf Moieties as New P2 Ligands in Non-Peptidal HIV-1 Protease Inhibitors (II). J.Med.Chem., 58:4029-, 2015 Cited by PubMed: 25897791DOI: 10.1021/ACS.JMEDCHEM.5B00358 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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