5AGH

Crystal structure of the LeuRS editing domain of Candida albicans Mutant K510A

5AGH の概要

• エントリーDOI: 10.2210/pdb5agh/pdb
• 関連するPDBエントリー: 5AGI 5AGJ 5AH5
• 分子名称: POTENTIAL CYTOSOLIC LEUCYL TRNA SYNTHETASE, ACETATE ION (3 entities in total)
• 機能のキーワード: ligase, aminoacyl-trna synthetase, aminoacylation, protein synthesis, proof-reading mechanisms, antifungal target
• 由来する生物種: CANDIDA ALBICANS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29557.52

構造登録者

Zhao, H.,Palencia, A.,Seiradake, E.,Ghaemi, Z.,Luthey-Schulten, Z.,Cusack, S.,Martinis, S.A. (登録日: 2015-02-02, 公開日: 2015-07-01, 最終更新日: 2024-01-10)

• 主引用文献: Zhao, H.,Palencia, A.,Seiradake, E.,Ghaemi, Z.,Cusack, S.,Luthey-Schulten, Z.,Martinis, S.; Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight Into the Leucyl-tRNA Synthetase Editing Mechanism.; Acs Chem.Biol., 10:2277-, 2015; PubMed: 26172575; DOI: 10.1021/ACSCHEMBIO.5B00291

実験手法

X-RAY DIFFRACTION (1.81 Å)