5AE3

Ether Lipid-Generating Enzyme AGPS in complex with antimycin A

5AE3 の概要

• エントリーDOI: 10.2210/pdb5ae3/pdb
• 関連するPDBエントリー: 5ADZ 5AE1 5AE2
• 分子名称: ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 3-methylbutanoate, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: transferase, ether phospholipid, cancer, flavin
• 由来する生物種: CAVIA PORCELLUS (DOMESTIC GUINEA PIG)
• 細胞内の位置: Peroxisome: P97275
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 297379.67

構造登録者

Piano, V.,Benjamin, D.I.,Valente, S.,Nenci, S.,Marrocco, B.,Mai, A.,Aliverti, A.,Nomura, D.K.,Mattevi, A. (登録日: 2015-08-25, 公開日: 2015-09-09, 最終更新日: 2024-01-10)

• 主引用文献: Piano, V.,Benjamin, D.I.,Valente, S.,Nenci, S.,Marrocco, B.,Mai, A.,Aliverti, A.,Nomura, D.K.,Mattevi, A.; Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.; Acs Chem.Biol., 10:2589-, 2015; PubMed: 26322624; DOI: 10.1021/ACSCHEMBIO.5B00466

実験手法

X-RAY DIFFRACTION (2.18 Å)