5ADZ

Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1a

Summary for 5ADZ

Entry DOI	10.2210/pdb5adz/pdb
Related	5AE1 5AE2 5AE3
Descriptor	ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, FLAVIN-ADENINE DINUCLEOTIDE, (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide), ... (4 entities in total)
Functional Keywords	transferase, ether phospholipid, cancer, flavin
Biological source	CAVIA PORCELLUS (DOMESTIC GUINEA PIG)
Cellular location	Peroxisome: P97275
Total number of polymer chains	4
Total formula weight	296206.39
Authors	Piano, V.,Benjamin, D.I.,Valente, S.,Nenci, S.,Marrocco, B.,Mai, A.,Aliverti, A.,Nomura, D.K.,Mattevi, A. (deposition date: 2015-08-25, release date: 2015-09-23, Last modification date: 2024-01-10)
Primary citation	Piano, V.,Benjamin, D.I.,Valente, S.,Nenci, S.,Marrocco, B.,Mai, A.,Aliverti, A.,Nomura, D.K.,Mattevi, A. Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents. Acs Chem.Biol., 10:2589-, 2015 Cited by PubMed: 26322624 DOI: 10.1021/ACSCHEMBIO.5B00466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation