5AC0

ovis aries Aldehyde Dehydrogenase 1A1 in complex with a duocarmycin analog

5AC0 の概要

• エントリーDOI: 10.2210/pdb5ac0/pdb
• 関連するPDBエントリー: 5ABM 5AC1 5AC2
• 分子名称: RETINAL DEHYDROGENASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, aldehyde dehydrogenase activity, oxidation-reduction process
• 由来する生物種: OVIS ARIES (SHEEP)
• 細胞内の位置: Cytoplasm: P51977
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 111741.42

構造登録者

Koch, M.F.,Harteis, S.,Blank, I.D.,Pestel, G.,Tietze, L.F.,Ochsenfeld, C.,Schneider, S.,Sieber, S.A. (登録日: 2015-08-10, 公開日: 2015-08-26, 最終更新日: 2024-01-10)

• 主引用文献: Koch, M.F.,Harteis, S.,Blank, I.D.,Pestel, G.,Tietze, L.F.,Ochsenfeld, C.,Schneider, S.,Sieber, S.A.; Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues.; Angew.Chem.Int.Ed.Engl., 54:13550-, 2015; PubMed: 26373694; DOI: 10.1002/ANIE.201505749

実験手法

X-RAY DIFFRACTION (1.9 Å)