5ABW

Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases

5ABW の概要

• エントリーDOI: 10.2210/pdb5abw/pdb
• 分子名称: NEUTROPHIL ELASTASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1-(3-CHLOROPHENYL)-5-(3,5-DIMETHYLISOXAZOL-4-YL)-6-METHYL-N-[4-(METHYLSULFONYL)BENZYL]-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE, ... (5 entities in total)
• 機能のキーワード: trypsin family fold, protease, hydrolase, hydrolase-inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24521.89

構造登録者

von Nussbaum, F.,Li, V.M.,Schaefer, M. (登録日: 2015-08-10, 公開日: 2015-08-19, 最終更新日: 2020-07-29)

• 主引用文献: von Nussbaum, F.,Li, V.M.; Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.; Bioorg. Med. Chem. Lett., 25:4370-4381, 2015; PubMed: 26358162; DOI: 10.1016/j.bmcl.2015.08.049

実験手法

X-RAY DIFFRACTION (1.6 Å)