5AB9
Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole
Summary for 5AB9
Entry DOI | 10.2210/pdb5ab9/pdb |
Related | 5ABA |
Descriptor | CELLULAR TUMOR ANTIGEN P53, ZINC ION, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
Functional Keywords | transcription, cancer, tumor suppression, dna binding, cancer therapy, small-molecule stabilizers, molecular chaperone |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 50211.89 |
Authors | Joerger, A.C. (deposition date: 2015-08-04, release date: 2015-12-16, Last modification date: 2024-01-10) |
Primary citation | Joerger, A.C.,Bauer, M.R.,Wilcken, R.,Baud, M.G.J.,Harbrecht, H.,Exner, T.E.,Boeckler, F.M.,Spencer, J.,Fersht, A.R. Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23:2246-, 2015 Cited by PubMed: 26636255DOI: 10.1016/J.STR.2015.10.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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