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5AAN

Crystal structure of Drosophila NCS-1 bound to penothiazine FD44

Summary for 5AAN
Entry DOI10.2210/pdb5aan/pdb
DescriptorCG5907-PA, ISOFORM A, CALCIUM ION, N-phenothiazin-10-yl-2-piperidin-1-yl-ethanamide, ... (5 entities in total)
Functional Keywordscalcium sensor, calcium-binding protein
Biological sourceDROSOPHILA MELANOGASTER (FRUIT FLY)
Total number of polymer chains1
Total formula weight22502.28
Authors
Chaves-Sanjuan, A.,Infantes, L.,Sanchez-Barrena, M.J. (deposition date: 2015-07-27, release date: 2017-01-25, Last modification date: 2024-01-10)
Primary citationMansilla, A.,Chaves-Sanjuan, A.,Campillo, N.E.,Semelidou, O.,Martinez-Gonzalez, L.,Infantes, L.,Gonzalez-Rubio, J.M.,Gil, C.,Conde, S.,Skoulakis, E.M.,Ferrus, A.,Martinez, A.,Sanchez-Barrena, M.J.
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Proc. Natl. Acad. Sci. U.S.A., 114:E999-E1008, 2017
Cited by
PubMed: 28119500
DOI: 10.1073/pnas.1611089114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

数据于2024-03-27公开中

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