5AAN

Crystal structure of Drosophila NCS-1 bound to penothiazine FD44

5AAN の概要

• エントリーDOI: 10.2210/pdb5aan/pdb
• 分子名称: CG5907-PA, ISOFORM A, CALCIUM ION, N-phenothiazin-10-yl-2-piperidin-1-yl-ethanamide, ... (5 entities in total)
• 機能のキーワード: calcium sensor, calcium-binding protein
• 由来する生物種: DROSOPHILA MELANOGASTER (FRUIT FLY)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22502.28

構造登録者

Chaves-Sanjuan, A.,Infantes, L.,Sanchez-Barrena, M.J. (登録日: 2015-07-27, 公開日: 2017-01-25, 最終更新日: 2024-01-10)

• 主引用文献: Mansilla, A.,Chaves-Sanjuan, A.,Campillo, N.E.,Semelidou, O.,Martinez-Gonzalez, L.,Infantes, L.,Gonzalez-Rubio, J.M.,Gil, C.,Conde, S.,Skoulakis, E.M.,Ferrus, A.,Martinez, A.,Sanchez-Barrena, M.J.; Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.; Proc. Natl. Acad. Sci. U.S.A., 114:E999-E1008, 2017; PubMed: 28119500; DOI: 10.1073/pnas.1611089114

実験手法

X-RAY DIFFRACTION (1.6 Å)