5A8E
thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound
Summary for 5A8E
| Entry DOI | 10.2210/pdb5a8e/pdb |
| Descriptor | BETA1 ADRENERGIC RECEPTOR, SODIUM ION, 4-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-7-methyl-1H-indole-2-carbonitrile, ... (6 entities in total) |
| Functional Keywords | signaling protein, inverse agonist |
| Biological source | MELEAGRIS GALLOPAVO (TURKEY) |
| Total number of polymer chains | 1 |
| Total formula weight | 38254.05 |
| Authors | Sato, T.,Baker, J.G.,Warne, T.,Brown, G.A.,Congreve, M.,Leslie, A.G.W.,Tate, C.G. (deposition date: 2015-07-15, release date: 2015-09-30, Last modification date: 2024-01-10) |
| Primary citation | Sato, T.,Baker, J.,Warne, T.,Brown, G.,Leslie, A.,Congreve, M.,Tate, C. Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound Beta1-Adrenergic Receptor. Mol.Pharmacol., 88:1024-, 2015 Cited by PubMed: 26385885DOI: 10.1124/MOL.115.101030 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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